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MADRS
Clinician-rated. Rate each item 0–6 based on the past week (intermediate scores 1, 3, 5 allowed).
1.Apparent sadness
- [0]0 — No sadness
- [1]1 —
- [2]2 — Looks dispirited but brightens up
- [3]3 —
- [4]4 — Appears sad and unhappy most of the time
- [5]5 —
- [6]6 — Looks miserable all the time; extremely despondent
2.Reported sadness
- [0]0 — Occasional sadness in keeping with circumstances
- [1]1 —
- [2]2 — Sad or low but brightens without difficulty
- [3]3 —
- [4]4 — Pervasive feelings of sadness or gloominess
- [5]5 —
- [6]6 — Continuous or unvarying sadness; extreme despondency
3.Inner tension
- [0]0 — Placid; only fleeting inner tension
- [1]1 —
- [2]2 — Occasional feelings of edginess and unease
- [3]3 —
- [4]4 — Continuous feelings of inner tension or intermittent panic
- [5]5 —
- [6]6 — Unrelenting dread or anguish; overwhelming panic
4.Reduced sleep
- [0]0 — Sleeps as usual
- [1]1 —
- [2]2 — Slight difficulty dropping off or slightly reduced/light sleep
- [3]3 —
- [4]4 — Sleep reduced or broken by at least 2 hours
- [5]5 —
- [6]6 — Less than 2 or 3 hours sleep
5.Reduced appetite
- [0]0 — Normal or increased appetite
- [1]1 —
- [2]2 — Slightly reduced appetite
- [3]3 —
- [4]4 — No appetite; food is tasteless
- [5]5 —
- [6]6 — Needs persuasion to eat at all
6.Concentration difficulties
- [0]0 — No difficulties
- [1]1 —
- [2]2 — Occasional difficulties collecting thoughts
- [3]3 —
- [4]4 — Difficulties concentrating and sustaining thought
- [5]5 —
- [6]6 — Unable to read or converse without great difficulty
7.Lassitude
- [0]0 — Hardly any difficulty starting activities; no inertia
- [1]1 —
- [2]2 — Difficulties starting activities
- [3]3 —
- [4]4 — Difficulties starting simple routine activities
- [5]5 —
- [6]6 — Complete lassitude; unable to do anything without help
8.Inability to feel
- [0]0 — Normal interest in surroundings and other people
- [1]1 —
- [2]2 — Reduced ability to enjoy usual interests
- [3]3 —
- [4]4 — Loss of interest in surroundings; loss of feelings for friends/acquaintances
- [5]5 —
- [6]6 — Emotionally paralyzed; inability to feel anger, grief or pleasure
9.Pessimistic thoughts
- [0]0 — No pessimistic thoughts
- [1]1 —
- [2]2 — Fluctuating ideas of failure, self-reproach or self-depreciation
- [3]3 —
- [4]4 — Persistent self-accusations or definite but rational ideas of guilt/sin
- [5]5 —
- [6]6 — Delusions of ruin, remorse or unredeemable sin
10.Suicidal thoughts
- [0]0 — Enjoys life or takes it as it comes
- [1]1 —
- [2]2 — Weary of life; only fleeting suicidal thoughts
- [3]3 —
- [4]4 — Probably better off dead; suicidal thoughts common
- [5]5 —
- [6]6 — Explicit plans for suicide when there is an opportunity; active preparations
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