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MADRS

Clinician-rated. Rate each item 0–6 based on the past week (intermediate scores 1, 3, 5 allowed).

  1. 1.Apparent sadness

    • [0]0 — No sadness
    • [1]1 —
    • [2]2 — Looks dispirited but brightens up
    • [3]3 —
    • [4]4 — Appears sad and unhappy most of the time
    • [5]5 —
    • [6]6 — Looks miserable all the time; extremely despondent
  2. 2.Reported sadness

    • [0]0 — Occasional sadness in keeping with circumstances
    • [1]1 —
    • [2]2 — Sad or low but brightens without difficulty
    • [3]3 —
    • [4]4 — Pervasive feelings of sadness or gloominess
    • [5]5 —
    • [6]6 — Continuous or unvarying sadness; extreme despondency
  3. 3.Inner tension

    • [0]0 — Placid; only fleeting inner tension
    • [1]1 —
    • [2]2 — Occasional feelings of edginess and unease
    • [3]3 —
    • [4]4 — Continuous feelings of inner tension or intermittent panic
    • [5]5 —
    • [6]6 — Unrelenting dread or anguish; overwhelming panic
  4. 4.Reduced sleep

    • [0]0 — Sleeps as usual
    • [1]1 —
    • [2]2 — Slight difficulty dropping off or slightly reduced/light sleep
    • [3]3 —
    • [4]4 — Sleep reduced or broken by at least 2 hours
    • [5]5 —
    • [6]6 — Less than 2 or 3 hours sleep
  5. 5.Reduced appetite

    • [0]0 — Normal or increased appetite
    • [1]1 —
    • [2]2 — Slightly reduced appetite
    • [3]3 —
    • [4]4 — No appetite; food is tasteless
    • [5]5 —
    • [6]6 — Needs persuasion to eat at all
  6. 6.Concentration difficulties

    • [0]0 — No difficulties
    • [1]1 —
    • [2]2 — Occasional difficulties collecting thoughts
    • [3]3 —
    • [4]4 — Difficulties concentrating and sustaining thought
    • [5]5 —
    • [6]6 — Unable to read or converse without great difficulty
  7. 7.Lassitude

    • [0]0 — Hardly any difficulty starting activities; no inertia
    • [1]1 —
    • [2]2 — Difficulties starting activities
    • [3]3 —
    • [4]4 — Difficulties starting simple routine activities
    • [5]5 —
    • [6]6 — Complete lassitude; unable to do anything without help
  8. 8.Inability to feel

    • [0]0 — Normal interest in surroundings and other people
    • [1]1 —
    • [2]2 — Reduced ability to enjoy usual interests
    • [3]3 —
    • [4]4 — Loss of interest in surroundings; loss of feelings for friends/acquaintances
    • [5]5 —
    • [6]6 — Emotionally paralyzed; inability to feel anger, grief or pleasure
  9. 9.Pessimistic thoughts

    • [0]0 — No pessimistic thoughts
    • [1]1 —
    • [2]2 — Fluctuating ideas of failure, self-reproach or self-depreciation
    • [3]3 —
    • [4]4 — Persistent self-accusations or definite but rational ideas of guilt/sin
    • [5]5 —
    • [6]6 — Delusions of ruin, remorse or unredeemable sin
  10. 10.Suicidal thoughts

    • [0]0 — Enjoys life or takes it as it comes
    • [1]1 —
    • [2]2 — Weary of life; only fleeting suicidal thoughts
    • [3]3 —
    • [4]4 — Probably better off dead; suicidal thoughts common
    • [5]5 —
    • [6]6 — Explicit plans for suicide when there is an opportunity; active preparations

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